iPhone assembler Foxconn has bought an EV factory in Ohio in a $230M deal. The purchase was made from electric vehicle startup Lordstown Motors.
While a key Apple supplier buying an EV plant in the US will inevitably create speculation about potential Apple Car production, this appears unlikely …
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Apple employee activism is shifting the balance of power within the company, suggests a report today. It says that more employees are willing to speak out about issues which concern them – such as pay disparity – and feel more protected than they have in the past.
The evidence presented is mixed, but it does indicate there has been at least some shift in the culture of secrecy at the company …
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The Federal Communications Commission (FCC) is calling on carriers to implement better security protections against SIM-swap and port-out attacks.
These attacks are a common way for criminals to carry out identity theft, and take over anything from an Apple ID to a bank account …
The post Protections against SIM-swap and port-out attacks should be improved, says FCC appeared first on 9to5Mac.
Merck’s experimental oral drug for COVID-19, molnupiravir, reduced by around 50% the chance of hospitalization or death for patients at risk of severe disease, according to interim clinical trial results announced on Friday.
Merck and partner Ridgeback Biotherapeutics plan to seek U.S. emergency use authorization for the pill as soon as possible, and to submit applications to regulatory agencies worldwide. Due to the positive results, the Phase 3 trial is being stopped early at the recommendation of outside monitors.
“This is going to change the dialog around how to manage COVID-19,” Robert Davis, Merck’s chief executive officer, told Reuters.
If authorized, molnupiravir, which is designed to introduce errors into the genetic code of the virus, would be the first oral antiviral medication for COVID-19.
Rivals including Pfizer Inc and Swiss pharmaceutical Roche Holding AG are racing to develop an easy-to-administer antiviral pill for COVID-19 but so far, only antibody cocktails – which have to be given intravenously – are approved for treating non-hospitalized COVID-19 patients.
A planned interim analysis of 775 patients in Merck’s study found that 7.3% of those given molnupiravir were either hospitalized or had died by 29 days after treatment, compared with 14.1% of placebo patients. There were no deaths in the molnupiravir group, but there were eight deaths of placebo patients.
“Antiviral treatments that can be taken at home to keep people with COVID-19 out of the hospital are critically needed,” Wendy Holman, Ridgeback’s CEO, said in a statement.
In the trial, which enrolled patients around the world, molnupiravir was taken every 12 hours for five days.
The study enrolled patients with laboratory-confirmed mild-to-moderate COVID-19, who had symptoms for no more than five days. All patients had at least one risk factor associated with poor disease outcome, such as obesity or older age.
Merck said viral sequencing done so far shows molnupiravir is effective against all variants of the coronavirus, including highly transmissible Delta.
The company said rates of adverse events were similar for both molnupiravir and placebo patients, but did not give details of the side effects.
Merck has said data shows molnupiravir is not capable of inducing genetic changes in human cells, but men enrolled in its trials have to abstain from heterosexual intercourse or agree to use contraception. Women of child-bearing age cannot be pregnant and also have to use birth control.
Merck said it expects to produce 10 million courses of the treatment by the end of 2021, with more doses coming next year.
The company has a U.S. government contract to supply 1.7 million courses of molnupiravir at a price of $700 per course.
CEO Davis said Merck has similar agreements with other governments worldwide, and is in talks with more. The company said it plans to implement a tiered pricing approach based on country income criteria.
Merck has also agreed to license the drug to several India-based generic drugmakers, which would be able to supply the treatment to low- and middle-income countries.
Molnupiravir is also being studied in a Phase 3 trial for preventing coronavirus infection in people exposed to the virus.
Merck officials said it is unclear how long the FDA review of the drug will take.
“I believe that they are going to try to work with alacrity on this,” said Dean Li, head of Merck’s research labs.
The post Merck’s COVID-19 pill cuts risk of death, hospitalization by 50%: study appeared first on ARY NEWS.
Are you looking for a comfortable chair that is designed for your kids?
If so, then there are plenty of options available to choose from. In this article, we’ll go over everything you need to know about kids’ foam chairs and provide some insight into what type might be best suited for your child or children.
We will also provide a few simple guidelines on how to clean a foam chair for kids, but first, we will explain what a foam chair is.
A foam chair for kids is a chair that is made from dense, closed-cell foam and designed with young children in mind. The main advantages of using a kids’ foam chair instead of other seating options, such as a club chair for kids, are:
These factors tend to be more important than having a club chair for kids simply because you’ll probably be using the chair for a much more extended period before replacing it.
Because kids’ foam chairs are made from the same material as their larger counterparts, they provide the same benefits and should be just as comfortable and easy to clean. However, we will cover these topics in more detail later on.
For the most part, there is little difference between a club chair for kids and a foam chair. Both provide an exceptional level of comfort and ease of cleaning; however, there are some key differences that you should be aware of before making your purchase.
First, you have to decide if you are looking for a club chair or a foam chair. As stated before, they both serve the same purpose, but there are some subtle differences in durability and cost. A club chair is usually made from an upholstered seat with hardwood arms connected via swiveling ball bearings. On the other hand, a foam chair will usually have no components and be upholstered entirely with soft padding.
Another critical difference is that club chairs are usually made using more expensive processes than foam chairs. This means it’s possible to find a club chair made from higher quality materials; however, this is not always the case, and the quality of a club chair is typically dictated by how much it costs.
That’s why we recommend you compare foam chairs to see which one will be better suited for your needs. If you’re working with a tight budget, then you’ll probably want to go with a foam chair; however, if money is not an issue, then you may want to consider buying a club chair instead.
Amazon.com, they have a wide variety of chairs for kids. You can, for example, purchase egg chairs for kids at Amazon.com. Although offering several different models, there are one that we recommend in front of all the others.
The Delta Children foam snuggle chair ticks off all boxes for comfort, design, and safety here at ComfyBummy.com.
You can get it in several colors, including blue, grey mink velvet, light grey, purple, and a Marvel Avengers pattern perfect for adventurous kids.
With a small handle on the back, the chair becomes easy to carry with you. Above is a small gallery of product images you can check out.
The foam insert is made in the USA, making this an American foam chair for kids, which we value highly.
Product Dimensions: 25 inch W x 20.5 inch H x 18 inch D; Seat Size: 15 inch W x 13 inch L
The chair comes with a machine washable cover, so you won’t have to worry about handwashing it every time your little one has an accident. Although the fabric is soft and comfortable for kids, it’s also quite durable. Plus, there are no metal springs that could get caught in the material while you’re trying to clean up your child’s mess.
Just unzip the cover, remove the chair’s cotton filling and wash it on a cold water setting, then tumble dry on low or no heat. Make sure you place it into a mesh laundry bag to avoid loose stuffing pieces from spilling out all over through your washer drum.
The post Kids Foam Chairs – Everything You Need To Know appeared first on Comfy Bummy.
Scientists behind COVID-19 vaccines could be in the running to win the Nobel Prize for Medicine even though the pandemic is far from over.
Some scientists say it is just a matter of time: If the work that went into developing the vaccines is not recognised when this year’s prize is announced on Monday, it will win the award in years to come.
More than 4.7 million people have died from COVID-19 since the first cases of the novel coronavirus were registered in 2019, and many countries still live under severe restrictions intended to curb its spread.
But COVID-19 vaccines have helped some wealthy states return almost to normality while others are yet to receive vaccine doses in large quantities.
Among those seen by other scientists as potential winners of the Nobel Prize for Medicine are Hungarian-born Katalin Kariko and American Drew Weissman for their work on what are known as Messenger ribonucleic acid (mRNA) vaccines.
The mRNA vaccines developed by Moderna and by Pfizer and its German partner BioNTech have revolutionised the fight against the virus. They are quick to produce and highly effective.
“This technique will get the prize sooner or later, of that I am sure,” said Ali Mirazami, professor at the Department of Laboratory Medicine at the Karolinska Institute in Sweden. “The question is when.”
Traditional vaccines, which introduce a weakened or dead virus to stimulate the body’s immune system, can take a decade or more to develop. Moderna’s mRNA vaccine went from gene sequencing to the first human injection in 63 days.
The mRNA carries messages from the body’s DNA to its cells, telling them to make the proteins needed for critical functions, such as coordinating biological processes including digestion or fighting disease.
The new vaccines use laboratory-made mRNA to instruct cells to make the coronavirus’ spike proteins, which spur the immune system into action without replicating like the actual virus.
DECADES OF WORK
The mRNA was discovered in 1961 but it has taken scientists decades to cure the mRNA technique from problems such as instability and causing inflammatory conditions.
Developers now hope it can be used to treat both cancer and HIV (human immunodeficiency virus) in the future.
“In addition to the fact that they have been shown to generate a very effective immune response, you do not have to tailor the production every time you make a new vaccine,” said Adam Frederik Sander Bertelsen, Associate Professor at the University of Copenhagen and chief scientific officer at vaccine company Adaptvac.
“It has actually saved countless thousands of people due to its speed and efficiency, so I can well support that.” Kariko, 66, laid the groundwork for the mRNA vaccines and Weissman, 62, is her long-time collaborator.
“They are the brain behind the mRNA discovery,” said Mirazami. He added: “They might be too young, the (Nobel) committee usually wait until the recipients are in their 80s.”
Kariko, with colleagues at the University of Pennsylvania, made a breakthrough by figuring out how to deliver mRNA without kicking the immune system into overdrive.
The Nobel Prize was founded by dynamite inventor Alfred Nobel and is awarded for achievements in Medicine, Chemistry, Literature, Peace and Physics. This year’s winners are announced between Oct. 4 and 11, starting with Medicine.
The world’s most prestigious political accolade will be unveiled on Oct. 8. While the winner often seems a total surprise, those who follow it closely say the best way to guess is to look at the global issues most likely to be on the minds of the five committee members who choose.
With the COP26 climate summit set for the start of November in Scotland, that issue could be global warming. Scientists paint this summit as the last chance to set binding targets for reductions in greenhouse gas emissions for the next decade, vital if the world is to have hope of keeping temperature change below the 1.5 degree Celsius target to avert catastrophe.
That could point to Thunberg, the Swedish climate activist, who at 18 would be the second youngest winner in history by a few months, after Pakistan’s Malala Yousafzai.
“The committee often wants to send a message. And this will be a strong message to send to COP26, which will be happening between the announcement of the award and the ceremony,” Dan Smith, director of the Stockholm International Peace Research Institute, told Reuters.
Another big issue the committee may want to address is democracy and free speech. That could mean an award for a press freedom group, such as the Committee to Protect Journalists or Reporters Without Borders, or for a prominent political dissident, such as exiled Belarus opposition leader Sviatlana Tsikhanouskaya or jailed Russian activist Alexei Navalny.
A win for a journalism advocacy group would resonate “with the large debate about the importance of independent reporting and the fighting of fake news for democratic governance,” said Henrik Urdal, director of the Peace Research Institute Oslo.
A Nobel for either Navalny or Tsikhanouskaya would be an echo of the Cold War, when peace and literature prizes were bestowed on prominent Soviet dissidents such as Andrei Sakharov and Alexander Solzhenitsyn.
Oddsmakers also tip groups such as the World Health Organization or the vaccine sharing body COVAX, which are directly involved in the global battle against COVID-19. But prize watchers say this could be less likely than might be assumed: the committee already cited the pandemic response last year, when it chose the U.N. World Food Programme.
While parliamentarians from any country can nominate candidates for the prize, in recent years the winner has tended to be a nominee proposed by lawmakers from Norway, whose parliament appoints the prize committee.
Norwegian lawmakers surveyed by Reuters have included Thunberg, Navalny, Tsikhanouskaya and the WHO on their lists.
Microsoft’s latest Windows 11 operating system aims to make the current Windows experience finer with its design prettier and more user-friendly interface.
However, regardless of all the improvements and better UI, some of your important software might not work right in the new operating system. And thus downgrading or going back to Windows 10 might be the only way.
Don’t worry if you find yourself in this dilemma since going back to Windows 10 is pretty easy, and takes very little effort.
Step by step guide to downgrade your computer from Windows 11 to Windows 10:
Click on the Start button
Click on Settings
Under System, click on Recovery
Under Recovery Options click on Go Back
Select a reason and click ‘Next’
Click ‘No Thanks” when windows asks you to check for updates
Make sure you backup important information and click Next. In our experience, none of our critical files were deleted. But better to be safe than to be sorry.
Windows will warn you to use your Windows 10 password, so make sure you remember. If you do, click Next.
Finally, click Go back to Windows 10. Once you do, your computer will restart.
The post Step by step guide for downgrading instantly to Windows 10 appeared first on ARY NEWS.
In addition to all the updates for its operating systems, Apple also introduced SF Symbols 3 beta at WWDC 2021 in June. The new version of SF Symbols, which includes more than 600 new icons, is now available to the public as an official release.
The post Apple officially releases SF Symbols 3 and updates for San Francisco and New York fonts appeared first on 9to5Mac.